Find msds or sds, a coa, data sheets and more information. Please consult the material safety data sheet for information regarding hazards and safe handling practices. Appropriate management of therapy and complications is possible only when adequate. Forms inter and intrastrand dna adductscrosslinks, consequently blocking dna replication and transcription and inducing cell death 2, 12, 15. Ciswel, cisplatin injection, cisplatin manufacturer, cisplatin manufacturer in india, cisplatin price in india, cisplatin cost in india, cisplatin cost effective option, cisplatin msds created date.
The type of container had no effect on cisplatin decomposition. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Standard operating procedure for cisplatin in animals 1. Download msds pdf search msds currently available for download bioworld offers lasparaginase recombinant for your research at low price. Cisplatin cas 15663271 scbt santa cruz biotechnology. Safety data sheets free sds database chemical safety. Cisplatin 1 mgml sterile concentrate summary of product. Material may be irritating to the mucous membranes and upper respiratory tract.
Cisplatin dosing, indications, interactions, adverse effects. Jul 15, 2014 the platinum drugs cisplatin, carboplatin and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. If cisplatin contacts the skin or mucosa, immediately and thoroughly wash the skin with soap and water and flush the mucosa with water. Sheet provided by the manufacturer that summarizes the chemical properties. Current status and new developments is a collection of papers presented at a symposium sponsored by the university of alabama in birmingham comprehensive cancer center and the bristol laboratories in syracuse. Cisplatin is a platinumbased agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin nephrotoxicity and protection by milk thistle extract.
Cisplatin cas 15663271 calbiochem msds material safety data sheet or sds, coa and. Merck is providing safety data sheet sds information as a service to our customers and others seeking this information. Material safety data sheet of cisplatin contains identification of substance and details of the supplier of the safety data sheet. Dec 31, 2019 cisplatin injection is a clear, colorless, sterile aqueous solution. Skin reactions associated with accidental exposure to cisplatin may occur. Cisplatin gains entry into tubular cells via uptake by the oct2 system on the basolateral membrane of proximal tubular cells. Read complete cisplatin msds ciswel manufactured by getwell oncology a leader manufacturing complex oncology generics in india. Cisplatin may give allergic reactions in some patients. The first metal based anticancer drug sciencedirect. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Sds of cisplatin, safety data sheets, cas 15663271 chemblink. View product specific information, msds, references and buying faq. The name of your medicine is cisplatin 1 mgml concentrate for solution for infusion but in the rest of the leaflet it will be called cisplatin injection. The platinum compounds, in vivo, crosslink dna and interfere with cell division by mitosis.
Standard operating procedure for cisplatin in animals. It exerts its effects by covalent reaction with dna to produce interstrand and intrastrand dna crosslinks, and dnaprotein crosslinks. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. Cisplatin is also being studied in the treatment of other types of cancer. Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. The international hazard communication standard hcs mandates that chemical manufacturers must communicate a chemicals hazard information to chemical handlers by providing a safety data sheet. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Your dosage will be based on your medical condition, weight, and response to the. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following. It is believed to induce apoptosis through several mechanisms. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Download fulltext pdf the discovery and development of cisplatin article pdf available in journal of chemical education 835 may 2006 with 4,414 reads.
Sds are available online in the reference standards database, or upon request via the helpdesk the electronic versions of the european pharmacopoeia also include links. A safety data sheet, or sds, is a standardized document that contains occupational safety and health data. Cisplatin fda prescribing information, side effects and uses. Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains. Sigmaaldrich offers a number of cisplatin products. Cisplatin comes as a liquid that is injected into a vein over six to eight hours in a hospital or medical facility. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. Cisplatin side effects, dosage, interactions drugs. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. Cisplatin is an anticancer agent with some side effects. Pdf cisplatin nephrotoxicity and protection by milk.
Download fulltext pdf the discovery and development of cisplatin article pdf available in journal of chemical education 835 may 2006 with 4,236 reads. Slightly hazardous in case of skin contact irritant, permeator, of eye contact. Niosh list of antineoplastic and other hazardous drugs cdc. The chemistry of cisplatin in aqueous solution springerlink. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin sc202093 and oxaliplatin sc202270, that form dna adducts resulting in apoptosis. The information contained in each sds is based on data merck believes to be correct to the best of our knowledge at the date of its publication. Cisplatin is one of the best and first metalbased chemotherapeutic drugs see fig.
In order to for patients to be treated as a day case, the regimens have been modified as follows. Safety data sheets edqm european directorate for the. She used a horizontal laminarflow hood that directed the airflow. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Health hazards cisplatin is a potent platinumbased antineoplastic drug which is used to treat cancers including. Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. As of december 1, 2010 all safety data sheets of hazardous substances are provided according to the requirements of clp regulation ec no 12722008, adopting ghs and annex ii of reach regulation ec 19072006. The solubility of cisplatin at 4c was also studied for possible precipitation. Find patient medical information for cisplatin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Identification of the substancepreparation and the companyundertaking material name.
In this study, we examined the literature and found a significant number of studies 11. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6. Material safety data sheet of cisplatin abmole bioscience. Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. Cisplatin hydration guidelines for outpatients introduction there is increasing demand to treat more patients as outpatients. Apexbio cisplatininhibits dna synthesis,chemotherapy drug. From in vitro studies on isolated dna and cho cells, the adducts formed from the reaction of carboplatin with dna include the.
The traditional mechanism is that cisplatin enters the cell, interacts with the dna guanine bases and forms the inter or intrastrand chain crosslinking, then prevents the replication of dna. Safety data sheet formerly material safety data sheet. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. This information was last updated on september 5, 2003. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. Each 50 ml or 100 ml amber vial of infusion concentrate contains. Where legally required, the sds contains an annex with exposure scenarios. Storagestability the product is soluble in water at 25 c.